BAX anticorps (AA 31-130) (Biotin)

N° du produit ABIN6983127

Cet anticorps anti-BAX est un anticorps Souris Monoclonal détectant BAX dans WB, IHC (p) et IHC (fro). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour BAX anticorps (AA 31-130) (Biotin) (ABIN6983127)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BAX est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3C1

Détail du produit anti-BAX anticorps (Biotin)

Épitope: AA 31-130

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G.

Immunogène: KLH conjugated synthetic peptide derived from human Bax

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: Bax

Sujet:

Synonyms: apoptosis regulator BAX, Apoptosis regulator BAX cytoplasmic isoform beta, Apoptosis regulator BAX membrane isoform alpha, Bax isoform psi, BAX protein cytoplasmic isoform delta, Bax protein cytoplasmic isoform delta. antibody Bax protein cytoplasmic isoform gamma, Bax zeta, Bax-protein, Bcl-2-like protein 4, BCL2 associated X protein, BCL2L4, BAX_HUMAN.

Background: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].

ID gène: 581

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response