GRK2 anticorps (pSer670) (HRP)

N° du produit ABIN6987545

L’anticorps anti-GRK2 Polyclonal Lapin est utilisé pour la détection de GRK2 dans des échantillons de Humain. Il a été validé pour IHC (p) et IHC (fro).

Aperçu rapide pour GRK2 anticorps (pSer670) (HRP) (ABIN6987545)

Antigène: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRK2 est conjugé à/à la HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GRK2 anticorps (HRP)

Épitope: pSer670

Fonction: phospho-GRK2 (Ser670) Polyclonal Antibody, HRP Conjugated

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GRK2

Antigène: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Autre désignation: GRK2

Sujet:

Synonyms: GRK2 (phospho S670), p-GRK2 (phospho S670), G-protein coupled receptor kinase 2, ADRBK 1, ADRBK1, Adrenergic beta receptor kinase 1, BARK 1, BARK, BARK1, Beta adrenergic receptor kinase 1, Beta ARK 1, Beta ARK1, G Protein Coupled Receptor Kinase 2, G protein dependent receptor kinase 2, FLJ16718, GRK 2, ARBK1_HUMAN.

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].

ID gène: 156

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling