Bcl-2 anticorps (AA 51-150) (HRP)

N° du produit ABIN6988060

Cet anticorps Souris Monoclonal détecte spécifiquement Bcl-2 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Porc, Lapin, Mouton, Chien, Boeuf (Vache), Cobaye et Cheval.

Aperçu rapide pour Bcl-2 anticorps (AA 51-150) (HRP) (ABIN6988060)

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivité: Humain, Souris, Rat, Porc, Lapin, Mouton, Chien, Boeuf (Vache), Cobaye, Cheval

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Bcl-2 est conjugé à/à la HRP

Application: Western Blotting (WB)

Clone: 4D10

Détail du produit anti-Bcl-2 anticorps (HRP)

Épitope: AA 51-150

Réactivité croisée: Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Porc, Lapin, Rat, Mouton

Purification: Purified by Protein G.

Immunogène: KLH conjugated synthetic peptide derived from human Bcl-2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Bcl-2

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Autre désignation: Bcl-2

Sujet:

Synonyms: Apoptosis regulator Bcl 2, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, B cell lymphoma 2, Bcl 2, Bcl-2, Bcl2, BCL2 protein, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, B-cell, 2, Oncogene B-cell leukemia 2, BCL2_HUMAN.

Background: The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14,18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

ID gène: 596

UniProt: P10415

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling