IRAK1 anticorps (C-Term)

N° du produit ABIN6990232

Cet anticorps Lapin Polyclonal détecte spécifiquement IRAK1 dans WB, ELISA, IF, IP et ICC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour IRAK1 anticorps (C-Term) (ABIN6990232)

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Détail du produit anti-IRAK1 anticorps

Épitope: C-Term

Specificité: At least four isoforms of IRAK are known to exist, this antibody will detect all four isoforms. IRAK antibody is predicted to not cross-react with other members of the IRAK protein family.

Purification: IRAK Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-IRAK antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK. The immunogen is located within the last 50 amino acids of IRAK.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-4 μ,g/mL, IF: 20 μ,g/mL, ICC: 10 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunofluorescence and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IRAK Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IRAK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur IRAK1

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Autre désignation: IRAK

Sujet: IRAK Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ,B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

Poids moléculaire: Predicted: 77kD

Observed: 77 kD kDa

ID gène: 3654

UniProt: P51617

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades