ASK1 anticorps (N-Term)

N° du produit ABIN6990603

Cet anticorps anti-ASK1 est un anticorps Lapin Polyclonal détectant ASK1 dans WB et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour ASK1 anticorps (N-Term) (ABIN6990603)

Antigène: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ASK1 anticorps

Épitope: AA 390-440, N-Term

Purification: ASK1 Antibody is affinity chromatography purified via peptide column.

Immunogène: ASK1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human ASK1. The immunogen is located within amino acids 390 - 440 of ASK1.

Isotype: IgG

Information d'application

Indications d'application: ASK1 antibody can be used for the detection of ASK1 by Western blot at 1 - 2 μ,g/mL. 3

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ASK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ASK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ASK1

Antigène: ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))

Autre désignation: ASK1

Sujet: ASK1 Antibody: Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-α,-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.

ID gène: 4217

UniProt: Q99683

Pathways: Signalisation MAPK, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response