PAK2 anticorps (N-Term)

N° du produit ABIN6990664

Détail du produit anti-PAK2 anticorps

Antigène: PAK2 (P21-Activated Kinase 2 (PAK2))

Épitope: AA 20-70, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: PAK2 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-PAK2 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human PAK2. The immunogen is located within amino acids 20-70 of PAK2.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5-2 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PAK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PAK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PAK2

Antigène: PAK2 (P21-Activated Kinase 2 (PAK2))

Autre désignation: PAK2 (PAK2 Produits)

Synonymes: anticorps PAK65, anticorps PAKgamma, anticorps gamma-PAK, anticorps 5330420P17Rik, anticorps A130002K10Rik, anticorps AI836325, anticorps D16Ertd269e, anticorps PAK-2, anticorps mKIAA4182, anticorps pak2, anticorps cb422, anticorps kinase, anticorps zgc:91798, anticorps wu:fb71h01, anticorps si:dz198m22.1, anticorps pak65, anticorps pakgamma, anticorps PAKI, anticorps Pak3, anticorps CH73-159L23.1, anticorps wu:fc52b03, anticorps zgc:113857, anticorps p21 (RAC1) activated kinase 2, anticorps p21 protein (Cdc42/Rac)-activated kinase 2, anticorps p21 protein (Cdc42/Rac)-activated kinase 2a, anticorps p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog, anticorps p21 protein (Cdc42/Rac)-activated kinase 2b, anticorps PAK2, anticorps Pak2, anticorps pak2a, anticorps pak2.S, anticorps pak2b

Sujet: PAK2 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.

Poids moléculaire: Predicted: 58kD

Observed: 58 kD kDa

ID gène: 5062

NCBI Accession: NP_002568

UniProt: Q13177

Pathways: Signalisation MAPK, Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha