SCO2 anticorps (C-Term)

N° du produit ABIN6990718

Détail du produit anti-SCO2 anticorps

Antigène: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCO2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: SCO2 Antibody is affinity chromatography purified via peptide column.

Immunogène: SCO2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human SCO2. The immunogen is located within the last 50 amino acids of SCO2.

Isotype: IgG

Information d'application

Indications d'application: SCO2 antibody can be used for detection of SCO2 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SCO2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SCO2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SCO2

Antigène: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Autre désignation: SCO2 (SCO2 Produits)

Synonymes: anticorps CEMCOX1, anticorps MYP6, anticorps SCO1L, anticorps SCO cytochrome oxidase deficient homolog 2 (yeast), anticorps SCO2 cytochrome c oxidase assembly protein, anticorps SCO2, cytochrome c oxidase assembly protein, anticorps SCO2, anticorps Sco2

Sujet: SCO2 Antibody: Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.

Poids moléculaire: Predicted: 29 kDa

Observed: 33 kDa

ID gène: 9997

UniProt: O43819

Pathways: Transition Metal Ion Homeostasis, L'effet Warburg