FLT3 anticorps (AA 340-390)

N° du produit ABIN6991750

Cet anticorps Lapin Polyclonal détecte spécifiquement FLT3 dans WB, ELISA et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour FLT3 anticorps (AA 340-390) (ABIN6991750)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-FLT3 anticorps

Épitope: AA 340-390

Specificité: At least three isoforms of FLT3 are known to exist, this antibody will detect all isoforms.

Purification: FLT3 Antibody is affinity chromatography purified via peptide column.

Immunogène: FLT3 antibody was raised against an 18 amino acid synthetic peptide near the center of human FLT3. The immunogen is located within amino acids 340 - 390 of FLT3.

Isotype: IgG

Information d'application

Indications d'application: FLT3 antibody can be used for detection of FLT3 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: FLT3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: FLT3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: FLT3

Sujet: FLT3 Antibody: FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.

Poids moléculaire: 109 kDa

ID gène: 2322

NCBI Accession: NP_004110

UniProt: P36888

Pathways: Signalisation RTK