NOX3 anticorps (N-Term)

N° du produit ABIN6992044

Cet anticorps Lapin Polyclonal détecte spécifiquement NOX3 dans ELISA, WB, IHC (p) et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour NOX3 anticorps (N-Term) (ABIN6992044)

Antigène: NOX3 (NADPH Oxidase 3 (NOX3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOX3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-NOX3 anticorps

Épitope: AA 110-160, N-Term

Specificité: NOX3 antibody is human and mouse reactive. NOX3 is predicted to not cross-react with other NOX proteins.

Purification: NOX3 antibody is affinity chromatography purified via peptide column.

Immunogène: NOX3 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX3. The immunogen is located within amino acids 110 - 160 of NOX3.

Isotype: IgG

Information d'application

Indications d'application: NOX3 antibody can be used for detection of NOX3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NOX3 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NOX3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur NOX3

Antigène: NOX3 (NADPH Oxidase 3 (NOX3))

Autre désignation: NOX3

Sujet: The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3). It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4).

Poids moléculaire: Predicted: 62 kDa

Observed: 72 kDa

ID gène: 50508

NCBI Accession: NP_056533

UniProt: Q9HBY0