NADPH Oxidase 4 anticorps (N-Term)

N° du produit ABIN6992045

L’anticorps Lapin Polyclonal anti-NADPH Oxidase 4 a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter NADPH Oxidase 4 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour NADPH Oxidase 4 anticorps (N-Term) (ABIN6992045)

Antigène: NADPH Oxidase 4 (NOX4)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NADPH Oxidase 4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NADPH Oxidase 4 anticorps

Épitope: AA 70-120, N-Term

Specificité: NOX4 antibody is human, mouse, and rat reactive. At least four isoforms of NOX4 are known to exist. NOX4 is predicted to not cross-react with other NOX proteins.

Purification: NOX4 antibody is affinity chromatography purified via peptide column.

Immunogène: NOX4 antibody was raised against a 14 amino acid peptide near the amino terminus of human NOX4. The immunogen is located within amino acids 70 - 120 of NOX4.

Isotype: IgG

Information d'application

Indications d'application: NOX4 antibody can be used for detection of NOX4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NOX4 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NOX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur NADPH Oxidase 4

Antigène: NADPH Oxidase 4 (NOX4)

Autre désignation: NOX4

Sujet: The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX4 is is expressed in multiple tissues and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS) (2,3). Unlike other NOX proteins, NOX4 does not require cytosolic subunits and thus is constitutively active (4). The function of NOX4 remains unclear as it plays both protective and deleterious roles in cellular metabolism.

Poids moléculaire: Predicted: 64 kDa

Observed: 68 kDa

ID gène: 50507

NCBI Accession: NP_058627

UniProt: Q9NPH5

Pathways: Carbohydrate Homeostasis, Smooth Muscle Cell Migration