SARS-CoV-2 Spike anticorps (B.1.1.7 - alpha, P681H)

N° du produit ABIN6992311

Détail du produit anti-SARS-CoV-2 Spike anticorps

Antigène: SARS-CoV-2 Spike

Épitope: B.1.1.7 - alpha, P681H

Reactivité: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SARS-CoV-2 Spike est non-conjugé

Application: ELISA, Western Blotting (WB)

Purification: SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody was raised against a peptide corresponding to 12 amino acids near the center of SARS-CoV-2 UK variant (B.1.1.7) Spike protein. The immunogen is located within 650-700 amino acids of SARS-CoV-2 UK variant (B.1.1.7) Spike protein.

Isotype: IgG

Information d'application

Indications d'application: WB: 1 μ,g/mL. Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can specifically detect SARS-CoV-2 UK Variant (B.1.1.7) Spike S1 protein, but not SARS-CoV-2 WT Spike S1 protein by ELISA. It can also detect mutant peptide (681H), but not WT peptide (681P). All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SARS-CoV-2 Spike

Antigène: SARS-CoV-2 Spike

Abstract: SARS-CoV-2 Spike Produits

Synonymes: anticorps E2, anticorps E2 glycoprotein precursor, anticorps Surface Glycoprotein, anticorps S

Classe de substances: Viral Protein

Sujet:

In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7, was discovered in the United Kingdom. This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery. The transmission of UK variant (B.1.1.7 lineage) was increased at least 50 % . Increased severity and higher death rate were also found in UK variant. UK variant will not affect the effectiveness of COVID19 vaccine. One of the mutations associated with this lineage is a N501Y in the spike protein of the virus. It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence. B.1.1.7 viruses have also been shown to have a P681H in the cleavage site of spike protein. This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.

ID gène: 43740568