HMGB4 anticorps

N° du produit ABIN7239995

Détail du produit anti-HMGB4 anticorps

Antigène: HMGB4 (High Mobility Group Box 4 (HMGB4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGB4 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant protein of human HMGB4

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HMGB4

Antigène: HMGB4 (High Mobility Group Box 4 (HMGB4))

Autre désignation: HMGB4 (HMGB4 Produits)

Synonymes: anticorps HMGB4, anticorps dJ1007G16.5, anticorps 1700001F22Rik, anticorps AI326135, anticorps high mobility group box 4, anticorps high-mobility group box 4, anticorps HMGB4, anticorps Hmgb4

Sujet: High mobility group protein B4is atranscription factorthat in humans is encoded by theHMGB4gene.HMGB4 is strongly and preferentially expressed in the adult mouse testis and weakly in the brain, but not in many other tissues. HMGB4 associates with chromatin, and in transfection assays, in contrast to HMGB1, it acts as a potent transcriptional repressor. During spermatogenesis, HMGB4 is present in the euchromatin of late pachytene spermatocytes and haploid round spermatids, whereas stronger expression is observed during the elongation phase, where it localizes to the basal pole of the nucleus in a manner mutually exclusive with H1FNT (H1T2) localized at the apical pole. HMGB4 basal localization is lost in H1FNT-mutant spermatids, showing that H1FNT provides a positional cue for organizing chromatin domains within the nucleus. These results show that HMGB4 and H1FNT specify distinct chromatin domains at the apical and basal poles of the elongating spermatid nucleus.

Poids moléculaire: 22 kDa

UniProt: Q8WW32