NeuN anticorps

N° du produit ABIN7244510

Détail du produit anti-NeuN anticorps

Antigène: NeuN (RBFOX3) (RNA Binding Protein, Fox-1 Homolog 3 (RBFOX3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NeuN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Synthetic peptide of human RBFOX3

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:1000 IHC 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NeuN

Antigène: NeuN (RBFOX3) (RNA Binding Protein, Fox-1 Homolog 3 (RBFOX3))

Autre désignation: RBFOX3 (RBFOX3 Produits)

Synonymes: anticorps FOX-3, anticorps FOX3, anticorps HRNBP3, anticorps NEUN, anticorps Fox-3, anticorps Hrnbp3, anticorps NeuN, anticorps Neuna60, anticorps Neun, anticorps RGD1560070, anticorps RNA binding fox-1 homolog 3, anticorps RNA binding protein, fox-1 homolog (C. elegans) 3, anticorps RNA binding protein, fox-1 homolog 3, anticorps RBFOX3, anticorps Rbfox3

Sujet: Immunoprecipitation and mass spectrometry of the two major NeuN species at 45-50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

Poids moléculaire:

Observed_MW: Refer to figures

Calculated_MW: 34 kDa

NCBI Accession: NP_001076044

UniProt: A6NFN3