Shootin-1 (SHTN1) anticorps
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- Antigène Voir toutes Shootin-1 (SHTN1) Anticorps
- Shootin-1 (SHTN1)
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Inconjugué
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogène
- Synthetic peptide of human SHTN1
- Isotype
- IgG
- Top Product
- Discover our top product SHTN1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.78 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- Shootin-1 (SHTN1)
- Autre désignation
- SHTN1 (SHTN1 Produits)
- Synonymes
- anticorps Kiaa1598, anticorps Shootin1, anticorps mKIAA1598, anticorps shootin 1, anticorps SHTN1, anticorps Shtn1
- Sujet
- Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
- Poids moléculaire
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Observed_MW: Refer to figures
Calculated_MW: 72 kDa
- UniProt
- A0MZ66
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