ZZZ3 anticorps

N° du produit ABIN7245926

Détail du produit anti-ZZZ3 anticorps

Antigène: ZZZ3 (Zinc Finger, ZZ-Type Containing 3 (ZZZ3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZZZ3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human ZZZ3

Isotype: IgG

Information d'application

Indications d'application: IHC 1:40-1:250, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ZZZ3

Antigène: ZZZ3 (Zinc Finger, ZZ-Type Containing 3 (ZZZ3))

Autre désignation: ZZZ3 (ZZZ3 Produits)

Synonymes: anticorps 3110065C23Rik, anticorps 6430567E01Rik, anticorps AA408566, anticorps AI481057, anticorps AW556059, anticorps R75514, anticorps si:ch211-284g18.3, anticorps wu:fj98c02, anticorps ATAC1, anticorps RGD1565468, anticorps zinc finger ZZ-type containing 3, anticorps zinc finger, ZZ-type containing 3, anticorps ZZ-type zinc finger-containing protein 3, anticorps zinc finger, ZZ domain containing 3, anticorps ZZZ3, anticorps zzz3, anticorps LOC100619668, anticorps Zzz3

Sujet: ZZZ3 (ZZ-type zinc finger-containing protein 3) is a 903 amino acid protein that contains one HTH myb-type DNA-binding domain and one ZZ-type zinc finger. Phosphorylated upon DNA damage by ATM or ATR, ZZZ3 is a subunit of the ATAC complex, which is composed of GCN5, CRP2BP, ADA3, TADA2L, DR1, CCDC101, YEATS2, WDR5 and MBIP. The ATAC complex has histone acetyltransferase activity on histones H3 and H4. ZZZ3 is expressed as four isoforms produced by alternative splicing and is encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

UniProt: Q8IYH5

Pathways: Chromatin Binding