ZNHIT3 anticorps

N° du produit ABIN7248236

Détail du produit anti-ZNHIT3 anticorps

Antigène: ZNHIT3 (Zinc Finger, HIT-Type Containing 3 (ZNHIT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNHIT3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human ZNHIT3

Isotype: IgG

Information d'application

Indications d'application: IHC 1:40-1:250, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ZNHIT3

Antigène: ZNHIT3 (Zinc Finger, HIT-Type Containing 3 (ZNHIT3))

Autre désignation: ZNHIT3 (ZNHIT3 Produits)

Synonymes: anticorps Myohd1, anticorps Trip3, anticorps TRIP3, anticorps TRIP-3, anticorps zinc finger, HIT type 3, anticorps zinc finger HIT-type containing 3, anticorps zinc finger, HIT-type containing 3, anticorps Znhit3, anticorps ZNHIT3

Sujet: ZNHIT3 (zinc finger, HIT-type containing 3), also known as TRIP3 (thyroid receptor-interacting protein 3) or HNF-4a coactivator, is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR-mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4, and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

UniProt: Q15649