IL4 Receptor anticorps

N° du produit ABIN7258016

L’anticorps anti-IL4 Receptor Polyclonal Lapin est utilisé pour la détection de IL4 Receptor dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC.

Aperçu rapide pour IL4 Receptor anticorps (ABIN7258016)

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL4 Receptor est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-IL4 Receptor anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human IL4R (NP_000409.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IL4 Receptor

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: IL4R

Sujet: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

ID gène: 3566

UniProt: P24394

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process