IL4 Receptor anticorps (AA 201-300)

N° du produit ABIN740565

Détail du produit anti-IL4 Receptor anticorps

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Épitope: AA 201-300

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL4 Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Homologie: Rat,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IL4R

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-IL4 Receptor (ABIN740565)

Danelli, Frossi, Gri, Mion, Guarnotta, Bongiovanni, Tripodo, Mariuzzi, Marzinotto, Rigoni, Blank, Colombo, Pucillo: "Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment." dans: Cancer immunology research, Vol. 3, Issue 1, pp. 85-95, (2015) (PubMed).

Détails sur IL4 Receptor

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: IL4R (IL4R Produits)

Synonymes: anticorps IL4R, anticorps il-4ra, anticorps zgc:113063, anticorps CD124, anticorps IL-4RA, anticorps IL4RA, anticorps Il4ra, anticorps IL4, anticorps Il4r, anticorps interleukin 4 receptor, anticorps interleukin 4 receptor, tandem duplicate 1, anticorps interleukin 4 receptor, alpha, anticorps IL4R, anticorps il4r.1, anticorps Il4r, anticorps Il4ra

Sujet:

Synonyms: CD124, IL4RA, IL-4RA, Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL4R, 582J2.1

Background: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

ID gène: 3566

UniProt: P24394

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process