APH1A anticorps

N° du produit ABIN7258038

Cet anticorps Lapin Polyclonal détecte spécifiquement APH1A dans IF. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour APH1A anticorps (ABIN7258038)

Antigène: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APH1A est non-conjugé

Application: Immunofluorescence (IF)

Détail du produit anti-APH1A anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human APH1A (NP_001071096.1).

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur APH1A

Antigène: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Autre désignation: APH1A

Sujet: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

ID gène: 51107

UniProt: Q96BI3

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway