COL18A1 anticorps

N° du produit ABIN7259634

Détail du produit anti-COL18A1 anticorps

Antigène: COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COL18A1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human COL18A1 (NP_085059.2).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur COL18A1

Antigène: COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))

Autre désignation: COL18A1 (COL18A1 Produits)

Synonymes: anticorps KNO, anticorps KNO1, anticorps KS, anticorps cb371, anticorps cb529, anticorps fc96d06, anticorps sb:cb529, anticorps wu:fb47h10, anticorps wu:fb77g12, anticorps wu:fc50f04, anticorps wu:fc96d06, anticorps wu:fk02h12, anticorps kno, anticorps kno1, anticorps collagen type XVIII alpha 1 chain, anticorps collagen type XVIII alpha 1 chain a, anticorps collagen, type XVIII, alpha 1, anticorps collagen type XVIII alpha 1, anticorps COL18A1, anticorps col18a1a, anticorps Col18a1, anticorps col18a1

Sujet: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 240 kDa

Calculated_MW: 135 kDa/154 kDa/178 kDa

ID gène: 80781

UniProt: P39060