NUAK1 anticorps

N° du produit ABIN7259682

Détail du produit anti-NUAK1 anticorps

Antigène: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUAK1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human NUAK1 (NP_055655.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NUAK1

Antigène: NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Autre désignation: NUAK1 (NUAK1 Produits)

Synonymes: anticorps ARK5, anticorps AU014801, anticorps AW494241, anticorps B230104P22Rik, anticorps Omphk1, anticorps NUAK family kinase 1, anticorps NUAK family, SNF1-like kinase, 1, anticorps NUAK1, anticorps Nuak1

Sujet: NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.

Poids moléculaire:

Observed_MW: 74 kDa

Calculated_MW: 23 kDa/74 kDa

ID gène: 9891

UniProt: O60285