ROBO3 anticorps

N° du produit ABIN7261161

Détail du produit anti-ROBO3 anticorps

Antigène: ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROBO3 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human ROBO3 (NP_071765.2).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ROBO3

Antigène: ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))

Autre désignation: ROBO3 (ROBO3 Produits)

Synonymes: anticorps HGPPS, anticorps HGPS, anticorps RBIG1, anticorps RIG1, anticorps CG14345, anticorps CT17158, anticorps Robo-3, anticorps Robo3, anticorps dRobo-3, anticorps DmelCG5423, anticorps CG5423, anticorps ROBO3, anticorps robo3, anticorps DKFZp468G0223, anticorps Rbig1, anticorps Rig-1, anticorps Rig1, anticorps Robo3a, anticorps Robo3b, anticorps cb503, anticorps roundabout guidance receptor 3, anticorps roundabout 3, anticorps robo3, anticorps roundabout guidance receptor 3 L homeolog, anticorps roundabout, axon guidance receptor, homolog 3 (Drosophila), anticorps ROBO3, anticorps robo3, anticorps Robo3, anticorps LOC658818, anticorps robo3.L

Sujet: This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Poids moléculaire:

Observed_MW: 200 kDa

Calculated_MW: 110 kDa/148 kDa

ID gène: 64221

UniProt: Q96MS0