SCN3A anticorps (Intracellular)

N° du produit ABIN7043643

Cet anticorps anti-SCN3A Polyclonal Lapin (ABIN7043643) détecte spécifiquement SCN3A dans WB, IHC, IF, IC et IP. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour SCN3A anticorps (Intracellular) (ABIN7043643)

Antigène: SCN3A (Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCN3A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Immunoprecipitation (IP)

Détail du produit anti-SCN3A anticorps

Épitope: AA 511-524, Intracellular

Fonction: A Rabbit Polyclonal Antibody to SCN3A (NaV1.3) Channel

Specificité: Intracellular, loop between domains I and II

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - 12,14 amino acid residues identical

Attributs du produit: Anti-SCN3A (NaV1.3) Antibody (ABIN7043643, ABIN7045227 and ABIN7045228) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, and immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize NaV1.3 from rat, human, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)HLEGNHRADGDRFP, corresponding to amino acid residues 511-524 rat NaV1.3

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7236843)

Blocking Peptide: (ABIN7236843)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur SCN3A

Antigène: SCN3A (Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A))

Autre désignation: SCN3A

Sujet: BIII, Brain type III Na+ channel, Sodium channel protein type 3 subunit alpha,Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7NaV1.3, also known as SCN3A, is highly expressed in embryonic sensory neurons and CNS, but its level dramatically decreases in adult rodents.8 Up-regulation of NaV1.3 channel expression was described in injured neurons and injured spinal cord.9-11

Alternative names: SCN3A (NaV1.3), BIII, Brain type III Na+ channel, Sodium channel protein type 3 subunit alpha

ID gène: 497770

NCBI Accession: NM_006922

UniProt: P08104