Recombinant CD28 anticorps

N° du produit ABIN7072327

Cet anticorps Souris Monoclonal détecte spécifiquement CD28 dans FACS, ELISA, Func, Act, BP et in vivo. Il présente une réactivité envers Chien.

Aperçu rapide pour Recombinant CD28 anticorps (ABIN7072327)

Antigène: CD28

Type d'anticorp: Recombinant Antibody

Reactivité: Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD28 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func), Activation (Act), Blocking Peptide (BP), In vivo Studies (in vivo)

Clone: 1C6

Détail du produit anti-CD28 anticorps

Fonction: Anti-CD28 [1C6], Mouse IgG1, kappa

Specificité: The antibody binds specifically to canine CD28, a self-surface receptor expressed by thymocytes and a subset of natural killer cells. CD28 acts as a receptor for CD80 and CD86, providing a costimulatory signal for the activation of T-cells and the production of interleukins, such as IL-6.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: Canine CD28.

Isotype: IgG1 kappa

Information d'application

Indications d'application: This antibody exhibits an antagonistic activity, blocking mixed lymphocyte reactions and cytotoxic T lymphocyte-mediated killing. The use of this antibody to neutralize the CD26 signal following T-cell receptor activation is of clinical importance for transplantation therapy, as it has been shown to prevent graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT). Interestingly, this antibody also exhibits agnostic activity, it was coated onto magnetic beads and used for the activation of canine peripheral blood lymphocytes (Szopa et al., 2021, PMID: 33679741).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD28

Antigène: CD28

Autre désignation: CD28

Sujet: TP44, Costimulatory molecule B7 receptor CD28, T-cell costimulatory molecule CD28

UniProt: Q9N0N8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response