anticorps GDN, anticorps GDNPF, anticorps PI-7, anticorps PI7, anticorps PN-1, anticorps PN1, anticorps PNI, anticorps SERPINE2, anticorps MGC143011, anticorps Gdnpn1, anticorps Pn-1, anticorps Spin4, anticorps B230326M24Rik, anticorps PAI-1, anticorps Spi4, anticorps zgc:55929, anticorps serpin family E member 2, anticorps serine (or cysteine) peptidase inhibitor, clade E, member 2, anticorps serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2, anticorps SERPINE2, anticorps serpine2, anticorps Serpine2
Sujet
The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth.