FGFR2 anticorps

N° du produit ABIN7091110

L’anticorps Lapin Monoclonal anti-FGFR2 a été validé pour IHC (p). Il convient pour détecter FGFR2 dans des échantillons de Humain.

Aperçu rapide pour FGFR2 anticorps (ABIN7091110)

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FGFR2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: E2F12

Détail du produit anti-FGFR2 anticorps

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FGFR2

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur FGFR2

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Autre désignation: FGFR2

Sujet:

Synonyms: KGFR, KSAM, Bacteria expressed kinase, BEK, BEK fibroblast growth factor receptor, BFR 1, BFR1, CD 332, CD332, CD332 antigen, CEK 3, CEK3, CFD 1, CFD1, Craniofacial dysostosis 1, Crouzon syndrome, ECT 1, ECT 1, ECT1, FGF receptor, FGFR 2, FGFR-2, FGFR2_HUMAN, Fibroblast growth factor receptor 2, Hydroxyaryl protein kinase, Hydroxyaryl protein kinase, Jackson Weiss syndrome, JWS, JWS antibody K SAM, K sam protein, K sam protein, K-sam , Keratinocyte growth factor receptor 2, Keratinocyte growth factor receptor, Pfeiffer syndrome, Protein tyrosine kinase receptor like 14, TK14, TK25, Tyrosylprotein kinase, Tyrosylprotein kinase.

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

ID gène: 2263

UniProt: P21802

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding