AMFR anticorps

N° du produit ABIN7111885

Cet anticorps Lapin Polyclonal détecte spécifiquement AMFR dans WB, ELISA, IHC, IP et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour AMFR anticorps (ABIN7111885)

Antigène: AMFR (Autocrine Motility Factor Receptor (AMFR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AMFR est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-AMFR anticorps

Fonction: AMFR antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: autocrine motility factor receptor

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IF: 1:10-1:100, IHC: 1:20-1:200, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur AMFR

Antigène: AMFR (Autocrine Motility Factor Receptor (AMFR))

Autre désignation: AMFR

Sujet:

Synonyms: E3 ubiquitin-protein ligase AMFR|Autocrine motility factor receptor (AMF receptor)|RING finger protein 45|gp78|AMFR|RNF45

Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

Poids moléculaire: 73 kDa

ID gène: 267

UniProt: Q9UKV5

Pathways: ER-Nucleus Signaling