AMFR anticorps (AA 485-643)

N° du produit ABIN7150978

Détail du produit anti-AMFR anticorps

Antigène: AMFR (Autocrine Motility Factor Receptor (AMFR))

Épitope: AA 485-643

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AMFR est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase AMFR protein (485-643AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AMFR

Antigène: AMFR (Autocrine Motility Factor Receptor (AMFR))

Autre désignation: AMFR (AMFR Produits)

Synonymes: anticorps GP78, anticorps RNF45, anticorps gp78, anticorps wu:fi06e06, anticorps wu:fi37e05, anticorps zgc:63893, anticorps rnf45, anticorps autocrine motility factor receptor, anticorps autocrine motility factor receptor L homeolog, anticorps autocrine motility factor receptor a, anticorps autocrine motility factor receptor, amfr, anticorps putative autocrine motility factor receptor, amfr, anticorps AMFR, anticorps Amfr, anticorps amfr.L, anticorps amfra, anticorps amfr, anticorps AaeL_AAEL005881, anticorps CpipJ_CPIJ016043, anticorps Smp_047420

Sujet:

Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

Aliases: AMF receptor antibody, AMF receptor isoform 1 antibody, AMF receptor isoform 2 antibody, AMFR antibody, AMFR2_HUMAN antibody, Autocrine motility factor receptor antibody, Autocrine motility factor receptor precursor, isoform 1 antibody, Autocrine motility factor receptor precursor, isoform 2 antibody, E3 ubiquitin-protein ligase AMFR antibody, gp78 antibody, isoform 2 antibody, RING finger protein 45 antibody, RNF 45 antibody, RNF45 antibody

UniProt: Q9UKV5

Pathways: ER-Nucleus Signaling