CBFA2T3 anticorps

N° du produit ABIN7113057

Détail du produit anti-CBFA2T3 anticorps

Antigène: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFA2T3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: core-binding factor, runt domain, alpha subunit 2, translocated to, 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur CBFA2T3

Antigène: CBFA2T3 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3))

Autre désignation: CBFA2T3 (CBFA2T3 Produits)

Synonymes: anticorps A630044F12Rik, anticorps AI465270, anticorps AW229127, anticorps Cbfa2t3h, anticorps ETO-2, anticorps Eto2, anticorps MTGR2, anticorps MTG16a, anticorps MTG16b, anticorps ETO2, anticorps MTG16, anticorps ZMYND4, anticorps core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human), anticorps CBFA2/RUNX1 translocation partner 3, anticorps Cbfa2t3, anticorps CBFA2T3

Sujet: Synonyms:MTG16, MTGR2, ZMYND4 Background:Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A, interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed:15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed:11823486).

Poids moléculaire: 62-65kd

ID gène: 863

UniProt: O75081