DDIT3 anticorps (AA 1-169)

N° du produit ABIN7113561

Cet anticorps anti-DDIT3 est un anticorps Souris Monoclonal détectant DDIT3 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour DDIT3 anticorps (AA 1-169) (ABIN7113561)

Antigène: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDIT3 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 5H7

Détail du produit anti-DDIT3 anticorps

Épitope: AA 1-169

Fonction: DDIT3 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-169aa

Immunogen: DNA-damage-inducible transcript 3

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur DDIT3

Antigène: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Autre désignation: DDIT3

Sujet:

Synonyms: DNA damage-inducible transcript 3 protein (DDIT-3)|C/EBP zeta|C/EBP-homologous protein (CHOP)|C/EBP-homologous protein 10 (CHOP-10)|CCAAT/enhancer-binding protein homologous protein|Growth arrest and DNA damage-inducible protein GADD153|DDIT3|CHOP|CHOP10|GADD153

Background: CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.

Poids moléculaire: 30 kDa

ID gène: 1649

UniProt: P35638

Pathways: Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis