NSMCE2 anticorps

N° du produit ABIN7113691

Détail du produit anti-NSMCE2 anticorps

Antigène: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSMCE2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: non-SMC element 2, MMS21 homolog(S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur NSMCE2

Antigène: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Autre désignation: NSMCE2 (NSMCE2 Produits)

Synonymes: anticorps 1110014D18Rik, anticorps AI661537, anticorps RGD1305156, anticorps C8orf36, anticorps MMS21, anticorps NSE2, anticorps ZMIZ7, anticorps Non-SMC element 2, anticorps NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase, anticorps NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog, anticorps Smc5-6 complex non-SMC subunit 2, anticorps Nsmce2, anticorps NSMCE2, anticorps nsmce2.L, anticorps nse2

Sujet: Synonyms:C8orf36, MMS21 Background:E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

Poids moléculaire: 28 kDa

ID gène: 286053

UniProt: Q96MF7