FBXO6 anticorps

N° du produit ABIN7114053

Détail du produit anti-FBXO6 anticorps

Antigène: FBXO6 (F-Box Protein 6 (FBXO6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXO6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: F-box protein 6

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur FBXO6

Antigène: FBXO6 (F-Box Protein 6 (FBXO6))

Autre désignation: FBXO6 (FBXO6 Produits)

Synonymes: anticorps FBG2, anticorps FBS2, anticorps FBX6, anticorps Fbx6b, anticorps AA408845, anticorps Fbs2, anticorps Fbxo6b, anticorps Fbg2, anticorps FBXO6, anticorps fbg2, anticorps fbs2, anticorps fbx6, anticorps fbx6b, anticorps fbxo44, anticorps F-box protein 6, anticorps F-box protein 6 S homeolog, anticorps FBXO6, anticorps Fbxo6, anticorps fbxo6.S

Sujet: Synonyms:FBG2, FBS2, FBX6 Background:Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Poids moléculaire: 35 kDa

ID gène: 26270

UniProt: Q9NRD1