IFIT3 anticorps

N° du produit ABIN7115384

L’anticorps Lapin Polyclonal anti-IFIT3 a été validé pour WB, ELISA, IHC et IP. Il convient pour détecter IFIT3 dans des échantillons de Humain et Souris.

Aperçu rapide pour IFIT3 anticorps (ABIN7115384)

Antigène: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFIT3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-IFIT3 anticorps

Fonction: IFIT3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: interferon-induced protein with tetratricopeptide repeats 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:500-1:1000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur IFIT3

Antigène: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Autre désignation: IFIT3

Sujet:

Synonyms: Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3)|CIG49|ISG-60|Interferon-induced 60 kDa protein (IFI-60K)|Interferon-induced protein with tetratricopeptide repeats 4 (IFIT-4)|Retinoic acid-induced gene G protein (P60, RIG-G)|IFIT3|CIG-49|IFI60|IFIT4|ISG60

Background: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Poids moléculaire: 60 kDa

ID gène: 3437

UniProt: O14879