MAPK13 anticorps

N° du produit ABIN7116418

Cet anticorps Souris Monoclonal détecte spécifiquement MAPK13 dans WB et ELISA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour MAPK13 anticorps (ABIN7116418)

Antigène: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPK13 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1A1

Détail du produit anti-MAPK13 anticorps

Fonction: MAPK13 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: mitogen-activated protein kinase 13

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MAPK13

Antigène: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Autre désignation: MAPK13

Sujet:

Synonyms: Mitogen-activated protein kinase 13 (MAP kinase 13, MAPK 13)|Mitogen-activated protein kinase p38 delta (MAP kinase p38 delta)|Stress-activated protein kinase 4|MAPK13|PRKM13|SAPK4

Background: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Poids moléculaire: 42 kDa

ID gène: 5603

UniProt: O15264

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Hepatitis C, BCR Signaling, S100 Proteins