NCK1 anticorps

N° du produit ABIN7116754

Cet anticorps Lapin Polyclonal détecte spécifiquement NCK1 dans WB, IHC, ELISA, IF, FACS et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour NCK1 anticorps (ABIN7116754)

Antigène: NCK1 (NCK Adaptor Protein 1 (NCK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)

Détail du produit anti-NCK1 anticorps

Fonction: NCK1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: NCK adaptor protein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur NCK1

Antigène: NCK1 (NCK Adaptor Protein 1 (NCK1))

Autre désignation: NCK1

Sujet:

Synonyms: SH2/SH3 adapter protein NCK1|Cytoplasmic protein NCK1|NCK adapter protein 1 (Nck-1)|SH2/SH3 adapter protein NCK-alpha|NCK1|NCK

Background: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Poids moléculaire: 43 kDa

ID gène: 4690

UniProt: P16333

Pathways: TCR Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals