SUV39H2 anticorps

N° du produit ABIN7119617

L’anticorps Lapin Polyclonal anti-SUV39H2 a été validé pour WB et ELISA. Il convient pour détecter SUV39H2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SUV39H2 anticorps (ABIN7119617)

Antigène: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUV39H2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SUV39H2 anticorps

Fonction: SUV39H2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: suppressor of variegation 3-9 homolog 2(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SUV39H2

Antigène: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Autre désignation: SUV39H2

Sujet:

Synonyms: Histone-lysine N-methyltransferase SUV39H2|Histone H3-K9 methyltransferase 2 (H3-K9-HMTase 2)|Lysine N-methyltransferase 1B|Suppressor of variegation 3-9 homolog 2 (Su(var)3-9 homolog 2)|SUV39H2|KMT1B

Background: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1(CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Poids moléculaire: 53 kDa

ID gène: 79723

UniProt: Q9H5I1