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TRAIP anticorps

TRAIP Reactivité: Humain, Souris ELISA, WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7120031
  • Antigène Voir toutes TRAIP Anticorps
    TRAIP (TRAF Interacting Protein (TRAIP))
    Reactivité
    • 20
    • 1
    • 1
    Humain, Souris
    Hôte
    • 15
    • 4
    • 1
    Lapin
    Clonalité
    • 17
    • 3
    Polyclonal
    Conjugué
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TRAIP est non-conjugé
    Application
    • 10
    • 7
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Pureté
    ≥95 % as determined by SDS-PAGE
    Immunogène
    TRAF interacting protein
    Isotype
    IgG
    Top Product
    Discover our top product TRAIP Anticorps primaire
  • Indications d'application
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Date de péremption
    12 months
  • Antigène
    TRAIP (TRAF Interacting Protein (TRAIP))
    Autre désignation
    TRAIP (TRAIP Produits)
    Synonymes
    anticorps MGC81341, anticorps RNF206, anticorps TRIP, anticorps Trip, anticorps TRAF interacting protein, anticorps TRAF interacting protein L homeolog, anticorps TRAF-interacting protein, anticorps TRAIP, anticorps traip.L, anticorps Traip
    Sujet
    Synonyms:RNF206, TRIP Background:E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).
    Poids moléculaire
    53 kDa
    ID gène
    10293
    UniProt
    Q9BWF2
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