VPS35 anticorps

N° du produit ABIN7120708

Détail du produit anti-VPS35 anticorps

Antigène: VPS35 (Vacuolar Protein Sorting 35 (VPS35))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS35 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 35 homolog(S. cerevisiae)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IP: 1:200-1:1000, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur VPS35

Antigène: VPS35 (Vacuolar Protein Sorting 35 (VPS35))

Autre désignation: VPS35 (VPS35 Produits)

Synonymes: anticorps MEM3, anticorps PARK17, anticorps vps35, anticorps MGC81959, anticorps bZ34G2.3, anticorps si:rp71-34g2.3, anticorps wu:fa66e03, anticorps wu:fb95c08, anticorps zgc:136268, anticorps 23.m05999, anticorps Mem3, anticorps VPS35, anticorps DKFZp459E1510, anticorps CG5625, anticorps DVps35, anticorps Dmel\\CG5625, anticorps Dvps35, anticorps dvps35, anticorps AI647796, anticorps mem3, anticorps VPS35, retromer complex component, anticorps VPS35 retromer complex component L homeolog, anticorps VPS35 retromer complex component, anticorps vacuolar protein sorting 35 homolog (S. cerevisiae), anticorps vacuolar protein sorting-associated protein 35, anticorps vacuolar protein sorting 35, anticorps Vacuolar protein sorting 35, anticorps hypothetical protein, anticorps VPS35 retromer complex component S homeolog, anticorps retromer complex subunit Vps35, anticorps VPS35, anticorps vps35.L, anticorps vps35, anticorps Tc00.1047053511367.170, anticorps Tb10.70.5460, anticorps BBOV_IV009740, anticorps CC1G_12185, anticorps PTRG_08682, anticorps CMU_017400, anticorps PHATR_43830, anticorps MCYG_00751, anticorps MGYG_01212, anticorps EHI_086580, anticorps EHI_002990, anticorps EHI_041950, anticorps EHI_096520, anticorps Bm1_44045, anticorps LOC100285267, anticorps Vps35, anticorps PGTG_10018, anticorps Tsp_09825, anticorps vps35.S

Sujet: Synonyms:DKFZp434E1211, DKFZp434P1672, FLJ10752, FLJ13588, FLJ20388, hVPS35, Maternal embryonic 3, MEM3, Vesicle protein sorting 35, VPS35 Background:Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35, however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of FAM21C(PubMed:22070227). Mediates the association of the CSC with the WASH complex via FAM21(PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5(PubMed:20923837).

Poids moléculaire: 92 kDa

ID gène: 55737

UniProt: Q96QK1