CRYAB anticorps (Crystallin, alpha B)

Details for Product anti-CRYAB Antibody No. ABIN707906
Antigène
  • CMD1II
  • CRYA2
  • CTPP2
  • CTRCT16
  • HSPB5
  • MFM2
  • Crya-2
  • Crya2
  • HspB5
  • AACRYA
  • CRYAB
  • cryab
  • crystallin alpha B
  • crystallin, alpha B
  • hypothetical protein
  • crystallin, alpha B, a
  • CRYAB
  • Cryab
  • ZK1128.7
  • cryaba
Reactivité
Humain, Souris, Rat (Rattus)
424
272
236
104
38
30
13
10
6
6
4
4
3
Hôte
Lapin
275
150
8
1
Clonalité
Polyclonal
Conjugué
Cet anticorp CRYAB est non-conjugé
16
14
13
9
9
9
9
9
9
6
6
6
6
6
6
6
6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
319
189
170
95
85
81
78
27
22
3
3
2
2
2
1
Options
Immunogène KLH conjugated synthetic peptide derived from human Alpha B Crystallin.
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others CRYAB products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation alpha B Crystallin (CRYAB Antibody Extrait)
Sujet

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].

Synonyms: CRYAB, CRYA2, Alpha crystallin B chain, AACRYA, Alpha B crystalline, Alpha crystallin B chain, AlphaB crystalline, AlphaB-crystallin, Alpha-crystallin B chain, CRYAB_HUMAN, Crystallin alpha B, Crystallin alpha polypeptide 2, CTPP 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, HSPB5, NY REN 27 antigen, Renal carcinoma antigen NY REN 27, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component.

ID gène 1410
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Image no. 1 for anti-Crystallin, alpha B (CRYAB) antibody (ABIN707906) Paraformaldehyde-fixed, paraffin embedded mouse brain, Antigen retrieval by boiling i...
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