Kallikrein 5 anticorps (AA 36-177)

N° du produit ABIN7126457

Cet anticorps Souris Monoclonal détecte spécifiquement Kallikrein 5 dans IHC et IHC (f). Il présente une réactivité envers Humain.

Aperçu rapide pour Kallikrein 5 anticorps (AA 36-177) (ABIN7126457)

Antigène: Kallikrein 5 (KLK5)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Kallikrein 5 est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Détail du produit anti-Kallikrein 5 anticorps

Épitope: AA 36-177

Specificité: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human KLK5 protein (around aa 36-177) (exact sequence is proprietary)

Isotype: IgG2a

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human skin tissue (IHC). MCF-7 cell lysates.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Kallikrein 5

Antigène: Kallikrein 5 (KLK5)

Autre désignation: KLK5

Sujet: HK5, Kallikrein L2, Kallikrein like protein 2, Kallikrein related peptidase 5, Kallikrein-like protein 2 (KLKL2), Stratum corneum tryptic enzyme (SCTE),Kallikrein 5 (KLK5)
Cellular localisation: Secreted

Poids moléculaire: 33kDa

ID gène: 25818, 50915

UniProt: Q9Y337

Pathways: Système du Complément, Regulation of G-Protein Coupled Receptor Protein Signaling