Recombinant EIF2C3 anticorps

N° du produit ABIN7127326

Détail du produit anti-EIF2C3 anticorps

Antigène: EIF2C3 (Eukaryotic Translation Initiation Factor 2C3 (EIF2C3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp EIF2C3 est non-conjugé

Application: ELISA

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human AGO3

Clone: 4F7

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EIF2C3

Antigène: EIF2C3 (Eukaryotic Translation Initiation Factor 2C3 (EIF2C3))

Autre désignation: AGO3 (EIF2C3 Produits)

Synonymes: anticorps EIF2C3, anticorps Eif2c3, anticorps Argonaute3, anticorps ago3, anticorps eif2c3, anticorps eif2c3b, anticorps si:dkey-3n22.3, anticorps AW048688, anticorps C130014L07Rik, anticorps ARGONAUTE 3, anticorps T19E23.8, anticorps T19E23_8, anticorps argonaute 3, RISC catalytic component, anticorps argonaute RISC catalytic component 3b, anticorps argonaute RISC catalytic subunit 3, anticorps argonaute RISC catalytic component 3, anticorps ARGONAUTE 3, anticorps AGO3, anticorps Ago3, anticorps ago3b

Sujet:

Background: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713).

Aliases: Protein argonaute-3UniRule annotation, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3UniRule annotation, AGO3, EIF2C3

UniProt: Q9H9G7

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulatory RNA Pathways, EGFR Signaling Pathway, Neurotrophin Signaling Pathway