Recombinant SYNCRIP anticorps

N° du produit ABIN7127546

Détail du produit anti-SYNCRIP anticorps

Antigène: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SYNCRIP est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human hnRNP Q

Clone: 9C7

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SYNCRIP

Antigène: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Autre désignation: SYNCRIP (SYNCRIP Produits)

Synonymes: anticorps GRY-RBP, anticorps GRYRBP, anticorps HNRNPQ, anticorps HNRPQ1, anticorps NSAP1, anticorps PP68, anticorps hnRNP-Q, anticorps 2610109K23Rik, anticorps 4632417O19Rik, anticorps Nsap1, anticorps Nsap1l, anticorps pp68, anticorps nsap1, anticorps wu:fe02c03, anticorps wu:fe47h09, anticorps SYNCRIP, anticorps hnrpq1, anticorps gry-rbp, anticorps rp1-3j17.2, anticorps synaptotagmin binding cytoplasmic RNA interacting protein, anticorps synaptotagmin binding, cytoplasmic RNA interacting protein, anticorps synaptotagmin binding cytoplasmic RNA interacting protein S homeolog, anticorps SYNCRIP, anticorps Syncrip, anticorps syncrip, anticorps syncrip.S

Sujet:

Background: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation, seems not to be essential for GAIT complex function.

Aliases: Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein), SYNCRIP, HNRPQ NSAP1

UniProt: O60506