DDIT3 anticorps (pSer30)

N° du produit ABIN7138755

L’anticorps Lapin Polyclonal anti-DDIT3 a été validé pour WB et ELISA. Il convient pour détecter DDIT3 dans des échantillons de Humain.

Aperçu rapide pour DDIT3 anticorps (pSer30) (ABIN7138755)

Antigène: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDIT3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DDIT3 anticorps

Épitope: pSer30

Réactivité croisée: Humain, Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine30(V-L-S(p)-S-D) derived from Human CHOP .

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DDIT3

Antigène: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Autre désignation: DDIT3

Sujet:

Background:

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

Ubeda M, Habener JF (2003) J Biol Chem 278, 40514-20

Aliases: C/EBP homologous protein antibody, C/EBP Homology Protein antibody, C/EBP zeta antibody, C/EBP-homologous protein 10 antibody, C/EBP-homologous protein antibody, CCAAT/enhancer binding protein homologous protein antibody, CEBPZ antibody, CHOP 10 antibody, CHOP antibody, CHOP-10 antibody, CHOP10 antibody, DDIT 3 antibody, DDIT-3 antibody, Ddit3 antibody, DDIT3_HUMAN antibody, DNA Damage Inducible Transcript 3 antibody, DNA damage-inducible transcript 3 protein antibody, GADD 153 antibody, GADD153 antibody, Growth Arrest and DNA Damage Inducible Protein 153 antibody, Growth arrest and DNA damage inducible protein GADD153 antibody, Growth arrest and DNA damage-inducible protein GADD153 antibody, MGC4154 antibody

UniProt: P35638

Pathways: Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis