PTK2B anticorps (pTyr402)

N° du produit ABIN7138999

Cet anticorps anti-PTK2B est un anticorps Lapin Polyclonal détectant PTK2B dans WB, IHC, ELISA et IF. Adapté pour Humain.

Aperçu rapide pour PTK2B anticorps (pTyr402) (ABIN7138999)

Antigène: PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTK2B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-PTK2B anticorps

Épitope: pTyr402

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y(p)-A-E) derived from Human Pyk2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PTK2B

Antigène: PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

Autre désignation: PTK2B

Sujet:

Background: Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Gluck SL, et al. (2004) J Clin Invest, 114(12): 1696-1699
Benzing T, et al. (2001) Proc Natl Acad Sci U S A, 98(17): 9784-9789
Tian D, et al. (2002) Mol Cell Biol, 22(8): 2650-2662
Lu Z, et al. (2001) Mol Cell Biol, 21(12): 4016-4031
Krishnan HH, et al. (2006) J Virol, 80(3): 1167-1180

Aliases: CADTK antibody, CAK-beta antibody, CAKB antibody, CAKbeta antibody, Calcium regulated non receptor proline rich tyrosine kinase antibody, Calcium-dependent tyrosine kinase antibody, Cell adhesion kinase beta antibody, E430023O05Rik antibody, EC 2.7.10.2 antibody, FADK 2 antibody, FADK2 antibody, FAK2 antibody, FAK2_HUMAN antibody, Focal adhesion kinase 2 antibody, MGC124628 antibody, PKB antibody, Proline-rich tyrosine kinase 2 antibody, Protein kinase B antibody, Protein Tyrosine Kinase 2 Beta antibody, Protein-tyrosine kinase 2-beta antibody, PTK antibody, PTK2B antibody, PTK2B protein tyrosine kinase 2 beta antibody, PYK2 antibody, RAFTK antibody, RAFTK2 antibody, Related adhesion focal tyrosine kinase antibody

UniProt: Q14289

Pathways: EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling