EPH Receptor A2 anticorps (pTyr594)

N° du produit ABIN7139032

Cet anticorps anti-EPH Receptor A2 est un anticorps Lapin Polyclonal détectant EPH Receptor A2 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour EPH Receptor A2 anticorps (pTyr594) (ABIN7139032)

Antigène: EPH Receptor A2 (EPHA2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-EPH Receptor A2 anticorps

Épitope: pTyr594

Fonction: Phospho-EPHA2/EPHA5 (Tyr594) Antibody

Réactivité croisée: Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 594 (H-T-Y(p)-E-D) derived from Human EPHA2/5.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPH Receptor A2

Antigène: EPH Receptor A2 (EPHA2)

Autre désignation: EPHA2

Sujet:

Background:

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.

Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990).
Gregory S.G., Nature 441:315-321(2006).

Aliases: ARCC2 antibody, AW545284 antibody, CTPA antibody, CTPP1 antibody, CTRCT6 antibody, EC 2.7.10.1 antibody, Eck antibody, Eph receptor A2 antibody, EPHA2 antibody, EPHA2_HUMAN antibody, Ephrin receptor antibody, Ephrin receptor EphA2 antibody, Ephrin type A receptor 2 antibody, Ephrin type-A receptor 2 antibody, Epithelial cell kinase antibody, Epithelial cell receptor protein tyrosine kinase antibody, Myk 2 antibody, Myk2 antibody, Sek 2 antibody, Sek2 antibody, Soluble EPHA2 variant 1 antibody, Tyrosine protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor MPK-5 antibody, Tyrosine-protein kinase receptor SEK-2 antibody

UniProt: P29317

Pathways: Signalisation RTK