FLT3 anticorps (pTyr842)

N° du produit ABIN7139079

L’anticorps Lapin Polyclonal anti-FLT3 a été validé pour WB et ELISA. Il convient pour détecter FLT3 dans des échantillons de Humain.

Aperçu rapide pour FLT3 anticorps (pTyr842) (ABIN7139079)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FLT3 anticorps

Épitope: pTyr842

Fonction: Phospho-FLT3 (Tyr842) Antibody

Réactivité croisée: Souris

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 842(S-N-Y(p)-V-V) derived from Human FLT3 .

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: FLT3

Sujet:

Background:

FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Small D., Proc. Natl. Acad. Sci. U.S.A. 91:459-463(1994).
Rosnet O., Blood 82:1110-1119(1993).
Rosnet O., Genomics 9:380-385(1991).

Aliases: CD 135 antibody, CD135 antibody, CD135 antigen antibody, Fetal liver kinase 2 antibody, FL cytokine receptor antibody, Flk 2 antibody, Flk2 antibody, Flt 3 antibody, FLT-3 antibody, Flt3 antibody, FLT3_HUMAN antibody, FMS like tyrosine kinase 3 antibody, Fms related tyrosine kinase 3 antibody, Fms-like tyrosine kinase 3 antibody, Growth factor receptor tyrosine kinase type III antibody, Ly-72 antibody, OTTHUMP0000004234 antibody, Receptor type tyrosine protein kinase FLT3 antibody, Stem cell tyrosine kinase 1 antibody, Stk 1 antibody, STK-1 antibody, Stk1 antibody, Tyrosine protein kinase receptor FLT3 antibody, Tyrosine-protein kinase receptor FLT3 antibody

UniProt: P36888

Pathways: Signalisation RTK