ALOX12B anticorps (AA 484-663) (Biotin)

N° du produit ABIN7144525

Détail du produit anti-ALOX12B anticorps (Biotin)

Antigène: ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))

Épitope: AA 484-663

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALOX12B est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ALOX12B

Antigène: ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))

Autre désignation: ALOX12B (ALOX12B Produits)

Synonymes: anticorps ALOX12B, anticorps MGC107915, anticorps MGC85124, anticorps 12R-LOX, anticorps ARCI2, anticorps Aloxe2, anticorps e-LOX2, anticorps arachidonate 12-lipoxygenase, 12R type, anticorps arachidonate 12-lipoxygenase, 12R type S homeolog, anticorps ALOX12B, anticorps alox12b, anticorps alox12b.S, anticorps Alox12b

Sujet:

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

Aliases: ALOX12B antibody, Arachidonate 12-lipoxygenase antibody, 12R-type antibody, 12R-LOX antibody, 12R-lipoxygenase antibody, EC 1.13.11.- antibody, Epidermis-type lipoxygenase 12 antibody

UniProt: O75342

Pathways: Cell-Cell Junction Organization