BIRC2 anticorps (AA 1-300) (HRP)

N° du produit ABIN7145202

L’anticorps Lapin Polyclonal anti-BIRC2 a été validé pour ELISA. Il convient pour détecter BIRC2 dans des échantillons de Humain.

Aperçu rapide pour BIRC2 anticorps (AA 1-300) (HRP) (ABIN7145202)

Antigène: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC2 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-BIRC2 anticorps (HRP)

Épitope: AA 1-300

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Baculoviral IAP repeat-containing protein 2 protein (1-300AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BIRC2

Antigène: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Autre désignation: BIRC2

Sujet:

Background: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Aliases: API 1 antibody, API1 antibody, Apoptosis inhibitor 1 antibody, Baculoviral IAP repeat containing 2 antibody, Baculoviral IAP repeat containing protein 2 antibody, Baculoviral IAP repeat-containing protein 2 antibody, BIRC 2 antibody, BIRC2 antibody, BIRC2_HUMAN antibody, C IAP1 antibody, C-IAP1 antibody, Cellular inhibitor of apoptosis 1 antibody, cellular inhibitor of apoptosis protein 1 antibody, cIAP 1 antibody, cIAP1 antibody, HIAP 2 antibody, HIAP-2 antibody, HIAP2 antibody, IAP 2 antibody, IAP homolog B antibody, IAP-2 antibody, IAP2 antibody, Inhibitor of apoptosis protein 2 antibody, MIHB antibody, NFR2 TRAF signalling complex protein antibody, RING finger protein 48 antibody, RNF 48 antibody, RNF48 antibody, TNFR2 TRAF signaling complex protein 2 antibody, TNFR2-TRAF-signaling complex protein 2 antibody

UniProt: Q13490

Pathways: Apoptose, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades