ARFGEF2 anticorps (AA 200-317)

N° du produit ABIN7145776

Détail du produit anti-ARFGEF2 anticorps

Antigène: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Épitope: AA 200-317

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARFGEF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 protein (200-317AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ARFGEF2

Antigène: ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))

Autre désignation: ARFGEF2 (ARFGEF2 Produits)

Synonymes: anticorps AI463430, anticorps AW493672, anticorps BIG2, anticorps E230011G24Rik, anticorps Big2, anticorps PVNH2, anticorps dJ1164I10.1, anticorps ADP ribosylation factor guanine nucleotide exchange factor 2, anticorps ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), anticorps ARFGEF2, anticorps Arfgef2

Sujet:

Background: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles, the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.

Aliases: ARFGEF2 antibody, ARFGEP2 antibody, BIG2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 antibody, Brefeldin A-inhibited GEP 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 antibody

UniProt: Q9Y6D5