CDK5RAP3 anticorps (Regulatory Subunit) (Biotin)

N° du produit ABIN7147235

Détail du produit anti-CDK5RAP3 anticorps (Biotin)

Antigène: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Épitope: AA 42-292, Regulatory Subunit

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK5RAP3 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human CDK5 regulatory subunit-associated protein 3 protein (42-292AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CDK5RAP3

Antigène: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Autre désignation: CDK5RAP3 (CDK5RAP3 Produits)

Synonymes: anticorps cdkrap3, anticorps fb33h04, anticorps fc09c05, anticorps id:ibd2920, anticorps wu:fb33h04, anticorps wu:fc09c05, anticorps zgc:86863, anticorps CDK5RAP3, anticorps cdk5rap3, anticorps MGC82350, anticorps C53, anticorps HSF-27, anticorps IC53, anticorps LZAP, anticorps MST016, anticorps OK/SW-cl.114, anticorps PP1553, anticorps 1810007E24Rik, anticorps BC002318, anticorps C81486, anticorps CDK5 regulatory subunit associated protein 3, anticorps CDK5 regulatory subunit associated protein 3 L homeolog, anticorps cdk5rap3, anticorps CDK5RAP3, anticorps cdk5rap3.L, anticorps Cdk5rap3

Sujet:

Background: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

Aliases: C53 antibody, CDK5 activator binding protein C53 antibody, CDK5 activator-binding protein C53 antibody, CDK5 regulatory subunit associated protein 3 antibody, CDK5 regulatory subunit-associated protein 3 antibody, Cdk5rap3 antibody, CK5P3_HUMAN antibody, HSF 27 antibody, HSF27 antibody, IC53 antibody, Ischemic heart CDK5 activator binding protein C53 antibody, LXXLL/leucine zipper containing ARFbinding protein antibody, LZAP antibody, MST016 antibody, OK/SW cl.114 antibody, PP1553 antibody, Protein HSF-27 antibody

UniProt: Q96JB5